Ethanol‐induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4‐methylpyrazole
- 1 December 1977
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 7 (6) , 487-490
- https://doi.org/10.1111/j.1365-2362.1977.tb01640.x
Abstract
Infusion of ethanol (0.6 g/kg body wt) caused marked hypoglycaemia in subjects fasted for 36 h. Previous administration of the alcohol dehydrogenase (ADH) inhibitor 4‐methylpyrazole (4‐MP, 7 mg/kg body wt i.v.) strongly suppressed the ethanol‐induced hypoglycaemia. The rate of ethanol elimination was 84.6 mg/kg per hour. 4‐MP at the dose used caused a 21% reduction of ethanol elimination, but had no significant effect on blood acetaldehyde levels. 4‐MP also significantly suppressed the ethanol‐induced elevation of blood lactate and almost completely prevented the increase in the 3‐hydroxy‐butyrate/acetoacetate ratio, but had only a slight effect on the lactate/pyruvate ratio of venous blood. The results demonstrate that the hypoglycaemia and lactacidaemia produced by the oxidation of alcohol can be prevented by a dose of 4‐MP that diminishes or prevents the ethanol‐induced shift in the NAD‐coupled redox state of the liver.Keywords
This publication has 18 references indexed in Scilit:
- The determination of acetaldehyde in blological samples by head-space gas chromatographyAnalytical Biochemistry, 1977
- Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preferenceBiochemical Pharmacology, 1973
- Prevention of the acute ethanol-induced fatty liver by 4-methylpyrazoleLife Sciences, 1971
- Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazoleLife Sciences, 1970
- Alcohol hypoglycemia. VII. Further studies on the refractoriness of obese subjectsMetabolism, 1968
- ALCOHOL‐INDUCED HYPOGLYCAEMIA IN CHRONIC ALCOHOLICS WITH LIVER DISEASEActa Medica Scandinavica, 1968
- Alcohol HypoglycemiaNew England Journal of Medicine, 1966
- Alcohol Hypoglycemia: II. A Postulated Mechanism of Action Based on Experiments with Rat Liver Slices1Journal of Clinical Endocrinology & Metabolism, 1965
- ALCOHOL HYPOGLYCEMIA. I. CARBOHYDRATE METABOLISM OF PATIENTS WITH CLINICAL ALCOHOL HYPOGLYCEMIA AND THE EXPERIMENTAL REPRODUCTION OF THE SYNDROME WITH PURE ETHANOL*Journal of Clinical Investigation, 1963
- STUDIES ON THE MECHANISM OF ETHANOL-INDUCED HYPOGLYCEMIA*Journal of Clinical Investigation, 1963