A B CELL-SUPPRESSIVE IgG-ANTIIMMUNOGLOBULIN ANTIBODY INDUCED BY ALLOIMMUNIZATION
- 1 September 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 50 (3) , 502-505
- https://doi.org/10.1097/00007890-199009000-00028
Abstract
This study is an extension of our previous report that alloimmunization produces a serum factor that suppresses the lymphocytotoxic antibody response. The experiments presented herein show that: (1) serum and IgG of pretreated rats contain an antibody directed against the constant region of IgG; (2) the anti-IgG has strong anti-Fc-.gamma. and weak anti-Fab activity; (3) the antibody also reacts with IgM; (4) the antiimmunoglobulin is an autoantibody; and (5) the antiimunoglobulin suppresses the primary B cell response in vitro.This publication has 4 references indexed in Scilit:
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