Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
Top Cited Papers
- 20 June 2008
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 320 (5883) , 1651-1654
- https://doi.org/10.1126/science.1158160
Abstract
Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.Keywords
This publication has 20 references indexed in Scilit:
- Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens groupBMC Biology, 2007
- Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticityNature Genetics, 2004
- The Genomic Sequence of the Accidental Pathogen Legionella pneumophilaScience, 2004
- The ankyrin repeat as molecular architecture for protein recognitionProtein Science, 2004
- Anaplasma phagocytophilum AnkA binds to granulocyte DNA and nuclear proteinsCellular Microbiology, 2004
- Wolbachia pipientis: intracellular infection and pathogenesis in DrosophilaCurrent Opinion in Microbiology, 2004
- Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm systemMolecular Microbiology, 2003
- Complete genome sequence of the Q-fever pathogenCoxiellaburnetiiProceedings of the National Academy of Sciences, 2003
- Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]The Journal of cell biology, 1993
- A role for microtubules in sorting endocytic vesicles in rat hepatocytes.Proceedings of the National Academy of Sciences, 1992