Inhibition of Cholesterol Biosynthesis in the Rat by 3 -(2-diethylaminoethoxy)androst-5-en-17-one, hydrochloride
- 1 January 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 112 (1) , 233-236
- https://doi.org/10.3181/00379727-112-28003
Abstract
Summary 1. U-18666A, a new inhibitor of cholesterol biosynthesis, caused marked reduction in serum and liver sterols and appearance of desmosterol in livers of rats. 2. Reduction of serum sterols by U-18666A was obtained in animals in which hypercholesterolemia was induced with Triton WR-1339. 3. U-18666A increased incorporation of acetate-1-C14 into liver digitonin precipitable sterols fourfold and into liver fatty acids twofold. 4. Of several other compounds tested for cholesterol inhibitory activity, only hexestrol bis-β-diethylaminoethyl ether was found to cause appearance of desmosterol.Keywords
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