Prodrugs of peptides. 15. 4-Imidazolidinone prodrug derivatives of enkephalins to prevent aminopeptidase-catalyzed metabolism in plasma and absorptive mucosae
- 1 September 1991
- journal article
- Published by Elsevier in International Journal of Pharmaceutics
- Vol. 76 (1-2) , 113-122
- https://doi.org/10.1016/0378-5173(91)90349-s
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- Prodrugs of peptides. 10. Protection of di- and tripeptides against aminopeptidase by formation of bioreversible 4-imidazolidinone derivativesInternational Journal of Pharmaceutics, 1991
- Prodrugs of peptides. 8. In vitro study of intestinal metabolism and penetration of thyrotropin-releasing hormone (TRH) and its prodrugsInternational Journal of Pharmaceutics, 1990
- Mechanism of Nasal Absorption of Drugs. III: Nasal Absorption of Leucine EnkephalinJournal of Pharmaceutical Sciences, 1990
- Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: Similarities in rates and involvement of aminopeptidasesLife Sciences, 1986
- Peptides and Related Drugs: A Review of Their Absorption, Metabolism, and ExcretionDrug Metabolism Reviews, 1986
- Hydrolysis of leucine enkephalin in the nasal cavity of the rat — A possible factor in the low bioavailability of nasally administered peptidesBiochemical and Biophysical Research Communications, 1985
- Kinetics of reversible reactions of ampicillin with various aldehydes and ketones with formation of 4-imidazolidinonesInternational Journal of Pharmaceutics, 1985
- Prodrugs as drug delivery systems. XXX. 4-Imidazolidinones as potential bioreversible derivatives for the α-aminoamide moiety in peptidesInternational Journal of Pharmaceutics, 1984
- Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (“enkephalinase”) as neuropeptidaseLife Sciences, 1981
- ‘Acetaldehyde-enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine-enkephalin and leucine-enkephalinFEBS Letters, 1980