Enantiopure derivatives of 1,2-alkanediols: Substrate requirements of lipase B fromCandida antarctica
- 6 September 2000
- Vol. 12 (9) , 654-659
- https://doi.org/10.1002/1520-636x(2000)12:9<654::aid-chir2>3.0.co;2-3
Abstract
Efficient methods for kinetic resolution of 1‐phenoxy‐2‐butanol, 1‐phenylmethoxy‐2‐butanol, and 1‐phenoxy‐2‐pentanol were developed using lipase B from Candida antarctica as catalyst. Resolutions were performed in order to investigate the substrate requirements needed to obtain a high E‐value. The effect of the substrate structure on E is different for transesterifications in organic media as compared to hydrolysis. The influence of different acyl donors on the E‐value was also investigated. Chirality 12:654–659, 2000.Keywords
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