Chemotherapy of Sarcomas of the Limbs by Regional Perfusion

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Abstract
From 1957-1975, 113 patients with sarcoma of the extremities were treated with chemotherapy by regional perfusion, alone or as an adjunct to excisional surgery. Perfusion alone in 54 patients was associated with an early response rate of 83%, but only 4 patients had complete regression of tumor for > 3 mo. When perfusion was followed by immediate or delayed excision, better results were obtained. In 49 stage I patients and 24 stage II patients, cumulative survivals of 66% and 59% were obtained at 5 yr and 66% and 51% at 10 yr. The procedure was also useful in saving functional limbs by converting tumors to operability, and in the palliation of pain and ulceration.