Phase II Trial of Acivicin in Patients with Advanced Colorectal Carcinoma
- 1 June 1986
- journal article
- research article
- Published by Wolters Kluwer Health in American Journal of Clinical Oncology
- Vol. 9 (3) , 189-191
- https://doi.org/10.1097/00000421-198606000-00003
Abstract
Acivicin, an amino acid antibiotic, was administered to 36 adult patients with previously treated metastatic colorectal cancer. The starting dose for good-risk patients was 15 mg/m2/day given as a short intravenous infusion on 5 consecutive days every 3 weeks. Patients previously treated with radiation therapy, mitomycin, or nitrosoureas and those with inadequate bone marrow reserve received 12 mg/m2 on the same schedule. In 33 evaluable patients, one partial response occurred. Sixteen patients had stable disease with a median time to disease progression of 15 weeks (range 9–27) and a median survival of 8 months. The median survival of the whole group was, however, <6 months. Myelotoxicity was mild and resulted in no significant complications. Nonhematological toxicity primarily consisted of nausea, vomiting, drowsiness, depression, and altered mentation. Acivicin given by this schedule is inactive at these dose levels in previously treated patients with colorectal carcinoma.This publication has 3 references indexed in Scilit:
- PHASE-II STUDY OF ACIVICIN IN COLORECTAL-CARCINOMA - A NATIONAL CANCER INSTITUTE OF CANADA STUDY1984
- THERAPY FOR MOUSE-TUMORS AND HUMAN-TUMOR XENOGRAFTS WITH THE ANTI-TUMOR ANTIBIOTIC AT-1251979
- BIOCHEMICAL AND PHARMACOLOGICAL EFFECTS OF THE FERMENTATION-DERIVED ANTI-TUMOR AGENT, (ALPHA-S,5S)-ALPHA-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID (AT-125)1979