Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. .omega.-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids
- 1 November 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (11) , 1499-1501
- https://doi.org/10.1021/jm00221a028
Abstract
.omega.-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw [rat] edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue and 0.43 times as potent as idomethacin.This publication has 4 references indexed in Scilit:
- Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. Dihydro-10-oxofuro- and -thieno[3,2-c][1]benzoxepin-8-acetic acidsJournal of Medicinal Chemistry, 1977
- Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acidsJournal of Medicinal Chemistry, 1977
- A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS1949
- Darstellung der EsterEuropean Journal of Inorganic Chemistry, 1895