Effects Of Steroid Androgens On The Uptake And Distribution Of Zinc In Slices From Human Prostates.

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Abstract
Slices of human hyperplastic prostates were superfused with ±6 5Zn ± Cl2 in the absence or in the presence of testosterone or 5α -dihydrotestosterone or 5α-androstane-3α, 17β-diol. Uptake of ±6 5Zn ± Cl2 was not significantly changed by steroid androgens but the binding of ±6 5Zn± to the citrate of prostatic cytosol was generally significantly decreased by the tested steroids. The 5α-reduced androgens were more efficient than testosterone in decreasing bound zinc levels and increasing free zinc concentrations. Implications of these findings on the metabolism and differentiation of prostatic cells are discussed.