Chemical Radiosensitization and Quality of Cellular Damage in Bacteria Exposed to Gamma Rays

Publisher Website
Google Scholar
Abstract
Iodoacetic acid (IAA) and N-ethylmaleimide (NEM) when present during exposure of Streptococcus faecalis cells to .gamma. radiation enhance radiation-induced lethality under anoxic and aerated conditions. The changes brought about by this radiosensitization in cellular functions were studied with a view to elucidating the mechanism responsible for the increased loss of viability. The quality of cellular damage in chemical radiosensitization was investigated by correlating survival and the biosynthetic capacity of an irradiated cell population. The relationship between surviving fraction and extent of incorporation of 3H-thymidine into DNA was unaffected regardless of whether the sensitizers (IAA or NEM) were present or absent during irradiation under anoxia. Under aerated condition of irradiation the survival-DNA-labeling relationship was completely different in the presence and in the absence of the sensitizers.

This publication has 1 reference indexed in Scilit: