THE EFFECT OF VARIOUS ANTI-OESTROGENIC COMPOUNDS ON THE RETICULO-ENDOTHELIAL SYSTEM AND REPRODUCTIVE TRACT IN THE OVARIECTOMIZED MOUSE

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Abstract
SUMMARY: (1) Testosterone, progesterone, oestriol, 17α-ethynyl-19-nortestosterone and MER-25 were shown to inhibit the vaginal smear response and the uterine growth response to 17β-oestradiol and diethylstilboestrol. (2) Testosterone potentiated the stimulant effect of 17β-oestradiol on the reticulo-endothelial system (RES); but had no effect on the RE stimulation produced by diethylstilboestrol. (3) Progesterone had no effect on RE stimulation produced by 17β-oestradiol or diethylstilboestrol. (4) Oestriol and 17α-ethynyl-19-nortestosterone had no effect on RE stimulation produced by 17β-oestradiol; but both compounds inhibited the stimulant effect of diethylstilboestrol on the RES. (5) MER-25 inhibited RE stimulation produced by both 17β-oestradiol and diethylstilboestrol. (6) The effect of anti-oestrogens on oestrogen-produced RE stimulation was shown to depend on the nature of the stimulating oestrogen used.