Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors ofE. coliglutamyl-tRNA synthetase
- 1 February 2005
- journal article
- Published by Taylor & Francis in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 20 (1) , 61-68
- https://doi.org/10.1080/14756360400002007
Abstract
5'-O-[N-(L-glutamyl)-sulfamoyl] adenosine is a potent competitive inhibitor of E. coli glutamyl-tRNA synthetase with respect to glutamic acid (K(i) = 2.8 nM) and is the best inhibitor of this enzyme. It is a weaker inhibitor of mammalian glutamyl-tRNA synthetase (K(i) = 70 nM). The corresponding 5'-O-[N-(L-pyroglutamyl)-sulfamoyl] adenosine is a weak inhibitor (K(i) = 15 microM) of the E. coli enzyme.Keywords
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