Experience with zona drilling and zona cutting to improve fertilization rates of human oocytes in vitro
- 1 March 1991
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 6 (3) , 423-431
- https://doi.org/10.1093/oxfordjournals.humrep.a137352
Abstract
Zona drilling (ZD) and zona cutting (ZC) were used in an IVF programme to assist fertilization In semen defect patients. Twenty-seven patients consented to ZD where acidified Tyrode's was used to create a hole in the zona pellucida. In 19 patients, ZD increased the fertilization rate to 29% compared with 8% (PPP < 0.01) oocytes and embryos were degenerate after 42 h. Both ZD and ZC can increase the fertilization rate of sub-optimal semen, however, in our hands neither technique produced a pregnancy.Keywords
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