A reversible protecting group for the amide bond in peptides. Use in the synthesis of ‘difficult sequences’
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 369-372
- https://doi.org/10.1039/c39930000369
Abstract
N,O-Bis-Fmoc (fluoren-9-ylmethoxycarbonyl) derivatives of Nα-(2-hydroxy-4-methoxybenzyl)amino acids 5 are useful intermediates for the preparation of peptides with reversibly protected (tertiary) peptide bonds; their value in inhibiting interchain association during solid phase peptide synthesis is demonstrated.Keywords
This publication has 1 reference indexed in Scilit:
- Towards elimination of segment insolubility during SPPSPublished by Springer Nature ,1992