Failure of (+)-naloxone to accelerate feline colonic transit
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 46 (2) , 217-219
- https://doi.org/10.1007/bf02027320
Abstract
To determine whether the colonic transit accelerating effect of (−)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.) was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.This publication has 8 references indexed in Scilit:
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