A small‐molecule enhancer of autophagy decreases levels of Aβ and APP‐CTF via Atg5‐dependent autophagy pathway
Open Access
- 24 February 2011
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 25 (6) , 1934-1942
- https://doi.org/10.1096/fj.10-175158
Abstract
The hallmarks of Alzheimer's disease are the aggregates of amyloid‐β (Aβ) peptide and tau protein. Autophagy is one major cellular pathway leading to the removal of aggregated proteins. We examined t...Keywords
Funding Information
- National Institutes of Health (AG‐09464)
This publication has 50 references indexed in Scilit:
- Autophagy, a guardian against neurodegenerationSeminars in Cell & Developmental Biology, 2010
- The role of the Atg1/ULK1 complex in autophagy regulationCurrent Opinion in Cell Biology, 2010
- Rapamycin fed late in life extends lifespan in genetically heterogeneous miceNature, 2009
- Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complexNature Cell Biology, 2009
- Autophagy fights disease through cellular self-digestionNature, 2008
- Small molecules enhance autophagy and reduce toxicity in Huntington's disease modelsNature Chemical Biology, 2007
- Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceNature, 2006
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006
- The role of autophagy during the early neonatal starvation periodNature, 2004
- Influence of TOR kinase on lifespan in C. elegansNature, 2003