CLINICAL DETERMINATION OF THE SITES OF RED CELL SEQUESTRATION IN HEMOLYTIC ANEMIAS 1

Open Access
Publisher Website
Google Scholar
Abstract
The sites of deposition of Cr51 in man were determined by measuring body surface radioactivity after the injection into normal subjects of Cr51-labelled red cells, hemoglobin, and chronic chloride. Measurements made thereafter on 11 patients with hemolytic anemias of diverse kinds indicated that progressive accumulation of Cr51 in the spleen accompanying the disappearance of Cr51-labelled red cells from the blood stream characterizes active red cell sequestration. In determining the extent of this sequestration a simple expression may be employed (index of sequestration) which deducts that radioactivity initially present and due simply to the size of the splenic vascular bed from later values obtained over that organ. The methods described should in practice constitute a simple clinical method for determining the need for splenectomy.