The safety catch principle in solid phase peptide synthesis
- 1 January 1971
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications
- No. 12,p. 636-637
- https://doi.org/10.1039/c29710000636
Abstract
N-Protected amino-acid active esters react readily with polystyrenesulphonamide yielding, after deprotection, the poly(aminoacylsulphonamides): these polymers are suitable for solid phase peptide synthesis, the completed peptide being cleaved from the resin by methylation and hydrolysis or aminolysis.Keywords
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