Action of Tiadenol and Clofibrate on Biliary Excretions of Cholesterol and Bile Salts in Rats

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Abstract
Biliary excretion of cholesterol, phospholipids and bile salts and the excretion of labeled cholesterol injected i.v. were studied in rats treated for 1 or 3 wk with the hypolipidemic drugs tiadenol and clofibrate. Total biliary cholesterol concentration and output decreased in treated rats and the cholesterol solubility ratio increased. The excretion of labeled bile salts increased with both drugs; the excretion of labeled cholesterol increased with clofibrate and tended to decrease with tiadenol. The ratio of labeled bile salts/labeled cholesterol was higher with tiadenol than with clofibrate.

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