The Systemic and Coronary Hemodynamics of Tromethamine (THAM) in the Anesthetized Dog

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Abstract
The systemic and coronary hemodynamic effects of intravenous administration of Tromethamine (THAM) was studied in intact anesthetized mongrel dogs. When approximately 750 mg/kg of THAM was administered during a period of approximately 50 minutes blood pH was elevated from 7.26 to 7.42. In spite of this increase in blood pH significant changes did not occur in cardiac output, cardiac work, total peripheral resistance, coronary vascular resistance, or coronary blood flow. The cardiac rate and myocardial oxygen consumption increased significantly, whereas cardiac efficiency was reduced. These changes may well be nonspecific due to the hypertonicity or other characteristics of the THAM solution. There may be some support for nonspecific effect in the fact that the hemoglobin and hematocrit decreased suggesting hemodilution.

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