The Formation of Circulating Antibody in the Splenec Tomized Human Being Following Intravenous Injection of Heterologous Erythrocytes

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Abstract
Summary: Sixteen control and fourteen splenectomized patients were given a single intravenous injection of 1.0 ml of a 2.0 per cent suspension of washed sheep erythrocytes. All controls responded with a significant rise in antibody titer between nine to fourteen days after the injection. Thirteen out of fourteen splenectomized patients failed to respond with a significant rise in antibody titer during this same time interval. Splenectomy had been performed eight days to forty months prior to immunization. The possible significance of these findings is discussed in terms of three syndromes: acquired hemolytic anemia, idiopathic thrombocytopenia, and erythroblastosis foetalis.