Increased frequency of the S allele of the L-myc oncogene in non-Hodgkin's lymphoma
Open Access
- 1 April 1994
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 69 (4) , 759-761
- https://doi.org/10.1038/bjc.1994.143
Abstract
We studied 100 patients with non-Hodgkin's lymphoma, 44 patients with Hodgkin's disease and 100 controls for the prevalence of the EcoRI restriction fragment polymorphism of the L-myc oncogene. No difference in the frequency of the three genotypes (LL, LS, SS) was found between the patient and control groups. However, the S allele was found to occur more frequently in the non-Hodgkin's lymphoma patients (chi 2 = 4.57, P = 0.032). These data confirm an earlier report and suggest that the presence of the S allele is associated with susceptibility to non-Hodgkin's lymphoma.Keywords
This publication has 15 references indexed in Scilit:
- Correlation of L‐myc RFLP with metastasis, prognosis and multiple cancer in lung‐cancer patientsInternational Journal of Cancer, 1992
- Correlation of L-myc Genotypes to Metastasis of Gastric Cancer and Breast CancerJNCI Journal of the National Cancer Institute, 1990
- Elevated frequency of a specific allele of the l‐MYC gene in male patients with bone and soft‐tissue sarcomasInternational Journal of Cancer, 1990
- Restriction fragment length polymorphism of the l‐myc gene and susceptibility to metastasis in renal cancer patientsInternational Journal of Cancer, 1989
- A simple method for DNA purification from peripheral bloodAnalytical Biochemistry, 1988
- Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs.Proceedings of the National Academy of Sciences, 1988
- L-myc, a new myc-related gene amplified and expressed in human small cell lung cancerNature, 1985
- Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.Proceedings of the National Academy of Sciences, 1985
- Alkaline transfer of DNA to plastic membraneBiochemical and Biophysical Research Communications, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983