Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
- 1 March 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 344 (6264) , 309-313
- https://doi.org/10.1038/344309a0
Abstract
Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.Keywords
This publication has 28 references indexed in Scilit:
- Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.Proceedings of the National Academy of Sciences, 1989
- Molecular analysis of the human beta-globin locus activation region.Proceedings of the National Academy of Sciences, 1989
- An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.Proceedings of the National Academy of Sciences, 1989
- A dominant control region from the human β-globin locus conferring integration site-independent gene expressionNature, 1989
- A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.Genes & Development, 1989
- The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific mannerCell, 1989
- Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybridsNucleic Acids Research, 1987
- Position-independent, high-level expression of the human β-globin gene in transgenic miceCell, 1987
- A developmentally stable chromatin structure in the human beta-globin gene cluster.Proceedings of the National Academy of Sciences, 1986
- The "beta-like-globin" gene domain in human erythroid cells.Proceedings of the National Academy of Sciences, 1985