Unique Specificity of Mouse Angiotensinogen to Homologous Renin

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Abstract
Summary Angiotensinogen contained in mouse plasma reacts exclusively with mouse kidney extract containing renin, to release angiotensin. Renin or kidney extracts from other species (pig, rat, hamster, rabbit) as well as from man do not liberate angiotensin if incubated with mouse plasma substrate. Plasma from nephrectomized mice, when incubated with mouse kidney extract, gave about 6 to 7 times higher yields of angioten-sin-like substance. Administration of DCA together with salt loading for a period of 3 weeks reduced renin activity in mouse kidneys, but not as markedly as in rats. The resistance of mouse renin substrate to heter-ologous renin appears unique among non-primates.

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