Distribution of Administered Fluid in Mice Subjected to Tourniquet Shock

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Abstract
Methods are presented for the study of fluid distr. in traumatized mice, both with and without therapy. The fate of administered fluid was followed in mice subjected to tourniquet shock. Within 2-4 hrs. after saline, plasma or serum admn., most of the fluid could be recovered in the injured areas. . No measurable amt. of edema in the viscera or uninjured areas of these treated animals could be detected. The significance of these findings is discussed for the amt. of therapy required in the treatment of traumatic shock, and for the mechanism of the observed retention of Na and fluid.

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