Cytokines and legionellosis
- 1 September 1994
- journal article
- review article
- Published by Springer Nature in Biotherapy
- Vol. 7 (3-4) , 179-186
- https://doi.org/10.1007/bf01878484
Abstract
Recent studies have led to an enhanced understanding of the role of cell-mediated immunity and cytokines in Legionnaires' disease. In particular, the effect of interferon gamma on human mononuclear phagocyte iron metabolism and the role of iron availability inLegionella pneumophila intracellular multiplication in human monocytes has been elucidated. With this knowledge it is now possible to develop treatment strategies for Legionnaires' disease using interferon gamma and/or agents affecting human mononuclear phagocyte iron metabolism.Keywords
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