Fc Binding of IgG to Skeletal Muscle Tissue

Publisher Website
Google Scholar
Abstract
In vitro binding of human IgG to human skeletal muscle tissue was demonstrated by different serological techniques. The binding is dependent upon an intact Fc part of the molecule and the results of the experiments indicate that such binding (Fc binding) also occurs in vivo. The amounts of IgG bound to the tissue increased with increasing concentrations of IgG in sera. Corresponding binding was also demonstrated in rabbit and guinea pig. Fc binding of IgG to skeletal muscle tissue may be of importance in the pathogenesis of the IgG hypercatabolism of IgG observed in various muscular disorders.

This publication has 0 references indexed in Scilit: