Copper ion binding and enzyme inhibitory properties of the antithyroid drug methimazole
- 1 September 1975
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 31 (9) , 1005-1006
- https://doi.org/10.1007/bf02326924
Abstract
The antithyroid drug, methimazole (1-methyl-2-thiolimidazole), is a powerful chelator of cupric ion. This is reflected in its ability to selectively inhibit certain copper oxidases. Uricase, ascorbic oxidase and monoamine oxidase are not affected. Ceruloplasmin oxidase is slightly inhibited and tyrosinase is markedly inhibited by methimazole.Keywords
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