A Comparison of Amino Acid Sequences of Hepatitis B Virus S Gene in 46 Children Presenting Various Clinical Features for Immunoprophylaxis.
- 1 January 1996
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 180 (3) , 233-247
- https://doi.org/10.1620/tjem.180.233
Abstract
We compared amino acid sequences of hepatitis B virus (HBV) S protein deduced from analyzed DNA sequence in 46 children who received immunoprophylaxis to prevent mother-to-child transmission of HBV. They were classified into 6 groups by their clinical features. The antibody escape mutants were found in 8 cases among 46 cases. We studied the difference in clinical features in these cases and speculated that 126 Ser or 140 Ser-strain may have a different behavior in relation to antibody to hepatitis B surface antigen from 126 Asn or 145 Arg-strain.Keywords
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