PROLONGED EFFECTS OF A POST‐SYNAPTIC BLOCKING FRACTION OF NAJA SIAMENSIS VENOM ON SKELETAL MUSCLE OF THE MOUSE

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Abstract
A subletal dose of a post-synaptic blocking fraction of N. siamensis venom was injected into the soleus muscle of the mouse inhibiting neuromuscular transmission for 2-days. The paralyzed soleus muscle behaved as if denervated, developing extra-junctional sensitivity to acetylcholine and accepting innervation by an implanted foreign nerve. Since the only known action of the post-synaptic blocking fraction of this venom is due to its affinity to acetylcholine receptors, the results suggest that the spread in the sensitivity of muscle fibers to acetylcholine and their ability to accept a foreign nerve is a consequence of neuromuscular blockade.

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