Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
- 16 July 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (14) , 3727-3731
- https://doi.org/10.1016/j.bmcl.2004.05.002
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitorsBioorganic & Medicinal Chemistry Letters, 2003
- Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitorsBioorganic & Medicinal Chemistry Letters, 2000
- Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic TemplatesJournal of Medicinal Chemistry, 1998
- In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitorsBioorganic & Medicinal Chemistry Letters, 1998
- Effects of Melagatran, a New Low-molecular-weight Thrombin Inhibitor, on Thrombin and Fibrinolytic EnzymesThrombosis and Haemostasis, 1998
- Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid SupportJournal of Medicinal Chemistry, 1998
- CVS-1123, A Direct Thrombin Inhibitor, Prevents Occlusive Arterial and Venous Thrombosis in a Canine Model of Vascular InjuryJournal of Cardiovascular Pharmacology, 1997
- Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profileTrends in Pharmacological Sciences, 1993
- Synthesis of Reserpine Analogs1,2The Journal of Organic Chemistry, 1959