FAILURE OF LACTOGENIC HORMONE TO MAINTAIN PREGNANCY INVOLUTION OF THE THYMUS

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Abstract
In recent papers [Grégoire, 1946, 1947] the factors involved in the maintenance of pregnancy involution of the thymus during suckling were studied, and it was concluded that endocrine, and not metabolic, factors were probably primarily concerned. It was suggested that variations in the secretion of anterior pituitary hormones (prolactin, adrenocorticotrophin) occurred under the influence of variations in suckling stimuli or milk removal, and that these changes prevented thymus regeneration in different degrees either directly or by altering the secretion of thymus-depressing hormones. The experiment reported here aimed to determine whether the injection of physiological doses of lactogenic hormone would prevent the regeneration of the thymus that takes place in females whose young are removed immediately after parturition. The few inconclusive reports of the influence of lactogenic hormone on the thymus and lymphoid tissue were reviewed in the earlier paper [Grégoire, 1947]. METHODS Animals Thirty-seven albino female rats of our strain

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