Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development
Open Access
- 1 August 1981
- journal article
- research article
- Published by The Company of Biologists in Development
- Vol. 64 (1) , 45-60
- https://doi.org/10.1242/dev.64.1.45
Abstract
Monoclonal antibodies (mAbs) against a preparation of intermediate filaments from trophoblastoma cells were studied for their reactivity pattern during embryonic development and on adult tissue cells. Up to day 12 of embryonic development, epithelial cells of the three germ layers reacted with these mAbs. Later during development and in adult tissues, positive reactions could be observed only with epithelial cells derived from mesoderm and endoderm. Because of their tissue distribution, the proteins reacting with these mAbs might belong to the keratin family of intermediate filaments or they might represent a new group of intermediate filaments.This publication has 14 references indexed in Scilit:
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