Brominations of Aliphatic Ketones by Copper(II) Bromide in Organic Solvents. II. The Reaction of Acetone with Copper(II) Bromide in N,N-Dimethylformamide

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Abstract
Because of a long induction period, the reaction between acetone and copper(II) bromide does not occur readily in pure DMF. However, in the presence of an acid, it proceeds readily. The initial rate is proportional to the product of the concentration of acetone and perchloric acid, but independent of the concentration of copper(II) bromide. The acid-catalyzed bromination of acetone by bromine has also been studied in DMF and found to obey the same second-order rate law as that in water. Both bromination reactions of acetone in DMF by copper(II) bromide and bromine were interpreted to be controlled by the enolization process of acetone.
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