METABOLISM OF HOMOLOGOUS AND HETEROLOGOUS SERUM PROTEINS IN BABY RABBITS

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  • 1 January 1961
    • journal article
    • research article
    • Vol. 4  (4) , 380-+
Abstract
The catabolism of 131I-labelled rabbit and human albumin and gamma globulin has been studied in baby rabbits from the 1st to the 6th week after birth. The half-lives, based in plasma concentrations corrected for growth, were approximately constant throughout this period, and were as follows: rabbit albumin and human albumin, about 6 days; rabbit gamma globulin and human gamma globulin, 12-14 days. Until the age of about 3 weeks, renal excretion of iodide was very inefficient. Consequently free 131I accumulated in the stomachs, and the whole body radioactivity greatly exceeded that due to retained labelled protein.