Matrix Metalloproteinase Expression Correlates with Virulence following Neurotropic Mouse Hepatitis Virus Infection
Open Access
- 1 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (15) , 7374-7384
- https://doi.org/10.1128/jvi.76.15.7374-7384.2002
Abstract
The relationship(s) between viral virulence and matrix metalloproteinase (MMP) expression in the central nervous system (CNS) of mice undergoing lethal and sublethal infections with neurotropic mouse hepatitis virus was investigated. Lethal infection induced increased levels of MMP-3 and MMP-12 mRNAs as well as that of tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) compared to sublethal infection. Increased induction of MMP, TIMP, and chemokine expression correlated with increased virus replication but not with inflammatory cell infiltration. Infection of immunosuppressed mice suggested that expression of most MMP, TIMP, and chemokine mRNA was induced primarily in CNS-resident cells. By contrast, MMP-9 protein activity was associated with the infiltration of neutrophils into the CNS. These data indicate an association between the magnitude of inflammatory gene expression within the CNS and viral virulence.Keywords
This publication has 62 references indexed in Scilit:
- Identification of Genes Involved in the Host Response to Neurovirulent Alphavirus InfectionJournal of Virology, 2001
- Morbillivirus Infection of the Mouse Central Nervous System Induces Region-Specific Upregulation of MMPs and TIMPs Correlated to Inflammatory Cytokine ExpressionJournal of Virology, 2001
- Mononuclear Phagocyte Differentiation, Activation, and Viral Infection Regulate Matrix Metalloproteinase Expression: Implications for Human Immunodeficiency Virus Type 1-Associated DementiaJournal of Virology, 2001
- Multiple sclerosis:: Pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-βJournal of Neuroimmunology, 2000
- Nuclear Factor κB Activity Is Essential for Matrix Metalloproteinase-1 and -3 Upregulation in Rabbit Dermal FibroblastsBiochemical and Biophysical Research Communications, 1999
- Leukocyte traffic in the central nervous system: the participants and their rolesSeminars in Immunology, 1999
- Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNSJournal of Neuroimmunology, 1998
- Differential matrix metalloproteinase expression in cases of multiple sclerosis and strokeNeuropathology and Applied Neurobiology, 1997
- Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediatedJournal of Neuroimmunology, 1990
- Murine Coronaviruses: Isolation and Characterization of Two Plaque Morphology Variants of the JHM Neurotropic StrainJournal of General Virology, 1982