Ventilatory Response to Carbon Dioxide After Epidural Clonidine Injection
- 1 June 1991
- journal article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 72 (6) , 761???764-4
- https://doi.org/10.1213/00000539-199106000-00007
Abstract
Stolic blood pressure). Heart rate decreased significantly by 10%—16% between 75 and 105 vain after injection. The slope of the ventilatory response to CO2 decreased significantly from 2.06 ± 0.70 (baseline) to 1.37 ± 0.68, 1.25 ± 0.65, and 1.33 ± 0.67 L-min−1-mm Hg−1 (mean ± SD, P < 0.05) at 15, 60, and 120 min. The authors conclude that epidural clonidine induces mild ventilatory and circulatory depression. Address correspondence to Dr. Penon, Departement d'Anes-thesiologie, Hopital de Bicetre, 94275 Kremlin-Bicetre Cedex, France. Presented in part at the annual meeting of the American Society of Anesthesiology, New Orleans, Louisiana, October 1989. Accepted for publication February 8, 1991. © 1991 International Anesthesia Research Society...Keywords
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