Effects of estrogen administration on serum testosterone in copenhagen rats

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Abstract
In order to develop a standard experimental method of exogenous estrogen therapy in the Copenhagen rat, several treatment regimens were evaluated to determine their effect on the serum testosterone. Diethylstilbestrol diphosphate (DES‐P) was administered either continuously in the drinking water or as a single intraperitoneal injection. Oral low‐dose estrogen (0.4‐1.6 μg/ml) yielded reliable suppression of serum testosterone to castrate levels. A single intraperitoneal injection of 0.5 mg DES‐P caused prompt suppression of serum testosterone with return to normal levels two weeks later.