Is a four‐state model sufficient to describe actomyosin ATPase?
- 29 January 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 260 (2) , 229-232
- https://doi.org/10.1016/0014-5793(90)80110-5
Abstract
Four- [(1984), J. Biol. Chem. 259, 11908] and six- [(1985) Science 227, 999] state models have been proposed for actomyosin ATPase. A key experiment in deciding between these is whether or not there is a transient Pi burst at high actin. In the first, the cleavage and release of products rates are similar and the Pi burst is low; in the second, there are additional product complexes and the Pi burst is large. We reinvestigated the problem by carrying out burst experiments under the conditions in [(1985) Science 227, 999]. Since we find that the Pi burst at high actin is low, we conclude that the four-state model is sufficient to describe actomyosin ATPase.Keywords
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