DYNAMICS OF INSULIN RELEASE BY PERFUSED HAMSTER (MESOCRICETUS AURATUS) PANCREASES: EFFECTS OF HYPOPHYSECTOMY, BOVINE AND HUMAN GROWTH HORMONE, AND PROLACTIN

1 May 1975

journal article
Published by Bioscientifica in Journal of Endocrinology

Vol. 65 (2) , 245-251
https://doi.org/10.1677/joe.0.0650245

Abstract

SUMMARY The hamster exhibits a biphasic pattern of insulin secretion; however, the dynamic response differs qualitatively from that of the rat in that there is a steady-state second release phase. A marked attenuation of insulin secretion as a result of hypophysectomy was observed after 3 weeks, but not after 2 weeks. This depression of insulin secretion was restored to near or above normal levels by bovine growth hormone, human growth hormone, and prolactin.

Keywords

INSULIN
BOVINE
HYPOPHYSECTOMY
BIPHASIC
HAMSTER
PERFUSED
MESOCRICETUS
AURATUS
PANCREASES

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