Studies on phosphonic acid antibiotics. IV. Synthesis and antibacterial activity of analogs of 3-(N-acetyl-N-hydroxyamino)-propylphosphonic acid (FR-900098).
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (1) , 111-118
- https://doi.org/10.1248/cpb.30.111
Abstract
The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino)propylphosphonic acid (FR-900098, Ia) and an analysis of their structure-activity relationship are described. Among them, compounds Ib (FR-31564) and XIIb (FR-32863) are produced naturally by Streptomyces lavendulae. The antibacterial activity of Ib against Pseudomonas sp. is especially significant.This publication has 7 references indexed in Scilit:
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