Multiple Effects of Phosphate Therapy

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Abstract
The recent recognition of inorganic (ortho) phosphate as a potential therapeutic agent in various disorders of calcium metabolism has stimulated a variety of studies of possible sites of action. The greatest interest in this "drug" has centered on its emergency use in life-threatening hypercalcemia; the invariable decrease in serum calcium during and after phosphate infusion has made such therapy the most rapid and predictable of the various possible approaches. It is this very predictability, and the virtual independence of renal function, that has led some investigators to conclude that a physicochemical effect was being observed and that precipitation or sequestration . . .