In VitroAntiviral Activity of Prodelphinidin B-2 3,3′-Di-O-gallate fromMyrica rubra

Publisher Website
Google Scholar
Abstract
In this study, the in vitro antiviral properties of prodelphinidin B-2 3,3′-di-O-gallate (PB233′OG) isolated from the bark of Myrica rubra (Myricaceae) was investigated. Results showed that PB233′OG exhibited anti-herpes simplex virus type 2 (HSV-2) activity with IC50 values of 5.3 ± 0.1 and 0.4 ± 0.04 μM for XTT and plaque reduction assays, respectively. The IC50 value increased with increasing MOI (multiplicity of infection). PB233′OG did not show a cellular cytotoxic effect at concentrations that possessed antiviral activity. Mechanistic studies demonstrated that PB233′OG inhibited HSV-2 attachment to the Vero cell, interfered with the penetration of HSV-2 into the Vero cell, affected the late stage(s) of the HSV-2 infection cycle, and also reduced the viral infectivity at high concentrations. It is concluded that PB233′OG exhibits various modes of action in its anti-HSV-2 effects.

This publication has 0 references indexed in Scilit: