The inhibitory binding site(s) of Zn2+in cytochromecoxidase
Open Access
- 18 January 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (4) , 611-616
- https://doi.org/10.1016/j.febslet.2007.01.017
Abstract
EXAFS identifies tetrahedral coordination site(s) for Zn2+ with two N‐histidine imidazoles, one N‐histidine imidazol or N‐lysine and one O–COOH (glutamate or aspartate), possibly located at the entry site of the proton conducting D pathway in the oxidase and involved in inhibition of the oxygen reduction catalysis and proton pumping by internally trapped zinc.Keywords
This publication has 35 references indexed in Scilit:
- Inhibition of proton pumping by zinc ions during specific reaction steps in cytochrome c oxidaseBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
- Mechanism of Proton Transfer Inhibition by Cd2+Binding to Bacterial Reaction Centers: Determination of the pKAof Functionally Important Histidine ResiduesBiochemistry, 2003
- The X-ray Crystal Structures of Wild-type and EQ(I-286) Mutant Cytochrome c Oxidases from Rhodobacter sphaeroidesJournal of Molecular Biology, 2002
- Group-fittedab initiosingle- and multiple-scattering EXAFS Debye-Waller factorsPhysical Review B, 2002
- X-ray Optics of a Dynamical Sagittal-Focusing Monochromator on the GILDA Beamline at the ESRFJournal of Synchrotron Radiation, 1996
- The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 ÅScience, 1996
- X-Ray Absorption Spectroscopic Investigations of Cytochrome c Oxidase Structure and FunctionAnnual Review of Biophysics, 1989
- Possible molecular mechanisms of the protonmotive function of cytochrome systemsJournal of Theoretical Biology, 1976
- Proton translocation reactions in the respiratory chainsBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1976
- Inhibition of the respiratory chain by zinc ionsBiochemical and Biophysical Research Communications, 1967