Plasma nortriptyline and clinical response–a study using changing plasma levels
- 1 February 1977
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 7 (1) , 87-91
- https://doi.org/10.1017/s0033291700023163
Abstract
Synopsis: In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured by the Hamilton Depression Scale, showed no significant relationships. The implications of the study are discussed.Keywords
This publication has 15 references indexed in Scilit:
- Observer variation and depressive phenomenologyPsychological Medicine, 1977
- Rapid radioisotopic procedure for determination of nortriptyline in plasma.Clinical Chemistry, 1976
- Assessment of Cardiovascular Side Effects of Therapeutic Doses of Tricyclic Anti‐depressant DrugsAustralian and New Zealand Journal of Medicine, 1975
- Letter: Effective dosage of tricyclic antidepressants.BMJ, 1975
- Plasma nortriptyline and clinical responseClinical Pharmacology & Therapeutics, 1974
- Long-term treatment of endogenous depression with nortriptyline with control of plasma levelsPsychological Medicine, 1974
- PLASMA-NORTRIPTYLINE LEVELS IN ENDOGENOUS DEPRESSIONThe Lancet, 1973
- PLASMA CONCENTRATION OF NORTRIPTYLINE AND CLINICAL RESPONSE IN DEPRESSIVE ILLNESSThe Lancet, 1972
- PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSEThe Lancet, 1972
- APPLICATION OF ISOTOPE DERIVATIVE TECHNIQUE TO ASSAY OF SECONDARY AMINES: ESTIMATION OF DESIPRAMINE BY ACETYLATION WITH H3-ACETIC ANHYDRIDEThe Journal of Pharmacology and Experimental Therapeutics, 1967