ProTherm: Thermodynamic Database for Proteins and Mutants
Open Access
- 1 January 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 27 (1) , 286-288
- https://doi.org/10.1093/nar/27.1.286
Abstract
The first release of the Thermodynamic Database for Proteins and Mutants (ProTherm) contains more than 3300 data of several thermodynamic parameters for wild type and mutant proteins. Each entry includes numerical data for unfolding Gibbs free energy change, enthalpy change, heat capacity change, transition temperature, activity etc., which are important for understanding the mechanism of protein stability. ProTherm also includes structural information such as secondary structure and solvent accessibility of wild type residues, and experimental methods and other conditions. A WWW interface enables users to search data based on various conditions with different sorting options for outputs. Further, ProTherm is cross-linked with NCBI PUBMED literature database, Protein Mutant Database, Enzyme Code and Protein Data Bank structural database. Moreover, all the mutation sites associated with each PDB structure are automatically mapped and can be directly viewed through 3DinSight developed in our laboratory. The database is available at the URL, http://www.rtc.riken.go.jp/protherm.htmlKeywords
This publication has 13 references indexed in Scilit:
- The Human Collagen Mutation Database 1998Nucleic Acids Research, 1998
- The human gene mutation databaseNucleic Acids Research, 1998
- The Human PAX6 Mutation DatabaseNucleic Acids Research, 1998
- Software and database for the analysis of mutations in the VHL geneNucleic Acids Research, 1998
- The Androgen Receptor Gene Mutations DatabaseNucleic Acids Research, 1998
- p53 gene mutation: software and databaseNucleic Acids Research, 1998
- SV40 large tumor antigen (T antigen): database of mutantsNucleic Acids Research, 1998
- Haemophilia B: database of point mutations and short additions and deletions--eighth editionNucleic Acids Research, 1998
- Software and database for the analysis of mutations in the human WT1 geneNucleic Acids Research, 1998
- Improved strategy in analytic surface calculation for molecular systems: Handling of singularities and computational efficiencyJournal of Computational Chemistry, 1993