Accelerated uptake of 5-hydroxytryptamine by human blood platelets enriched in a sialic acid
- 15 May 1975
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 148 (2) , 335-336
- https://doi.org/10.1042/bj1480335
Abstract
The enzymically catalysed incorporation of N-acetylneuraminic acid into human platelets, whether suspended in their own citrated plasma or in buffered saline containing 0.17 mM-sucrose, accelerated the uptake of 5-hydroxytryptamine. This acceleration decreased with time. The observations may be explained by assuming that N-acetylneuraminic acid is a component of a transport receptor for 5-hydroxytryptamine.Keywords
This publication has 9 references indexed in Scilit:
- Platelet Aggregation in Washed SuspensionsScandinavian Journal of Haematology, 2009
- Effect of 5-hydroxytryptamine on the potassium ion exchange of human platelets enriched in sialic acidBiochemical Journal, 1972
- Changes in the Aggregation of Platelets enriched in Sialic AcidNature New Biology, 1972
- Relative activities on and uptake by human blood platelets of 5‐hydroxytryptamine and several analoguesBritish Journal of Pharmacology, 1972
- Intracellular Localization of Liver Sugar Nucleotide Glycoprotein Glycosyltransferases in a Golgi-rich FractionJournal of Biological Chemistry, 1970
- 5‐Hydroxytryptamine uptake and release in relation to aggregation of rabbit plateletsThe Journal of Physiology, 1969
- The relation between the 5-hydroxytryptamine content and aggregation of rabbit plateletsThe Journal of Physiology, 1969
- Effects of the Numbers and Sizes of Platelet Aggregates on the Optical Density of PlasmaNature, 1967
- SIALIC ACIDS .X. PURIFICATION AND PROPERTIES OF CYTIDINE 5-MONOPHOSPHOSIALIC ACID SYNTHETASE1966