THE SERUM GLUTAMIC OXALOACETIC TRANSAMINASE SERUM GLUTAMIC PYRUVIC TRANSAMINASE RATIO AS A PROGNOSTIC INDEX IN SEVERE ACUTE VIRAL-HEPATITIS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 77  (1) , 2-4
Abstract
The serum glutamic oxaloacetic transaminase/serum glutamic pyruvic transaminase (SGOT/SGPT) ratio was studied in 25 patients with severe acute viral hepatitis due to either B or non-A, non-B hepatitis. The transaminase levels were performed within 10 days of onset of the hepatitis or within 4 days of the diagnosis of fulminant hepatic failure. Twelve patients died of their acute illness. There was a significant difference between the SGOT/SGPT ratios of females who died (mean = 2.05) and lived (mean 0.45) (P < 0.001) and between the SGOT/SGPT ratios of males who died (mean = 1.01) and lived (mean 0.45) (P < 0.02). Using 95% confidence intervals the expected ratios for combined sexes were calculated to be 0.31-0.63 for survivors and 1.20-2.26 for nonsurvivors. Neither age nor viral etiology affected the prognosis in this study.