Anticentromere and anticentriole antibodies in the scleroderma spectrum
- 1 July 1983
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 119 (7) , 560-566
- https://doi.org/10.1001/archderm.119.7.560
Abstract
• We studied serum samples from 106 patients, including 80 in the scleroderma spectrum, by indirect immunofluorescent microscopy, using PtK, rat kangaroo tissue culture cells as substrate. Anticentromere (Kinetochore) antibodies were present in 28 patients, and anticentriole antibodies were present in four patients. Anticentromere antibodies were usually present in patients with a benign, chronic form of systemic scleroderma, which has been termed theCREST(Calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia) syndrome. The four patients with a previously undescribed anticentriole antibody were all in the scleroderma spectrum. Possibly, these antibodies may have diagnostic and prognostic importance. Further, they will be useful in studying the structure and function of these cellular organelles. (Arch Dermatol1983;119:560-566)This publication has 3 references indexed in Scilit:
- Antibodies reacting with ribosomal ribonucleoprotein in connective tissue diseasesArthritis & Rheumatism, 1979
- Immunofluorescent Techniques in Clinical Diagnosis of Cutaneous DiseaseAnnals of Internal Medicine, 1969
- The Immunofluorescent Tumor Imprint TechniqueAnnals of Internal Medicine, 1966